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Gender differences and adherence of patients treated with wearable cardioverter-defibrillator: insights from an international multicenter register
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  • Mohammad Abumayyaleh,
  • Tobias C. Dreher ,
  • Ibrahim El-Battrawy,
  • Stephanie Rosenkaimer,
  • Susanne Röger,
  • Julia Erath,
  • Norbert Klein,
  • Boldizsar Kovacs,
  • Firat Duru,
  • Ardan Saguner,
  • Ibrahim Akin
Mohammad Abumayyaleh
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Tobias C. Dreher
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Ibrahim El-Battrawy
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Stephanie Rosenkaimer
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Susanne Röger
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Julia Erath
Goethe-Universitat Frankfurt am Main - Campus Westend
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Norbert Klein
Klinikum Sankt Georg gGmbH
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Boldizsar Kovacs
UniversitatsSpital Zurich Klinik fur Kardiologie
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Firat Duru
UniversitatsSpital Zurich Klinik fur Kardiologie
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Ardan Saguner
UniversitatsSpital Zurich Klinik fur Kardiologie
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Ibrahim Akin
Ruprecht-Karls-Universitat Heidelberg Medizinische Fakultat Mannheim
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Abstract

Aims The treatment with the wearable cardioverter defibrillator (WCD) may protect against sudden cardiac death (SCD) as a bridging therapy until a cardioverter-defibrillator may be implanted. We analyzed in a multicenter setting a consecutive patient cohort wearing WCD to explore gender differences. Methods and results We analyzed 708 consecutive patients, 579 from whom were males and 129 females (age, 60.5±14 vs. 61.6±17 years old; p=0.44). All patients were divided into age quartiles for analysis. While the rate of ischemic cardiomyopathy (ICM) as a cause of prescription of WCD was significantly higher in males as compared to females (42.7% vs. 26.4%; p=0.001), females received it more frequently due to non-ischemic cardiomyopathy (NICM) (55.8% vs. 42.7%); p=0.009). The wear time of WCD was equivalent in both groups (21.1±4.3 hours/days in males vs. 21.5±4.4 hours/days in females; p=0.27; and 62.6±44.3 days in males vs. 56.5±39 days in females; p=0.15). Mortality was comparable in both groups at 2-year-follow-up (6.8% in males vs. 9.7% in females; p=0.55). Appropriate WCD shocks and the incidence of device implantations were similar in both groups (2.4% in males vs. 3.9% in females; p=0.07) (35.1% in males vs. 31.8% in females; p=0.37), respectively. In age quartile analysis, compliance was observed more in older patients as compared to adult patients (87.8% vs. 68.3%; p<0.001). Conclusion Compliance for wearing WCD was excellent regardless of gender. Furthermore, mortality and the incidence of device implantations were comparable in both groups. Appropriate WCD shocks tended to be higher in females as compared to males.
17 Jan 2022Submitted to Journal of Cardiovascular Electrophysiology
17 Jan 2022Submission Checks Completed
17 Jan 2022Assigned to Editor
17 Jan 2022Reviewer(s) Assigned
01 Feb 2022Review(s) Completed, Editorial Evaluation Pending
07 Feb 2022Editorial Decision: Revise Minor
12 May 20221st Revision Received
17 May 2022Assigned to Editor
17 May 2022Submission Checks Completed
17 May 2022Reviewer(s) Assigned
22 May 2022Review(s) Completed, Editorial Evaluation Pending
30 May 2022Editorial Decision: Revise Minor
20 Jun 20222nd Revision Received
23 Jun 2022Assigned to Editor
23 Jun 2022Submission Checks Completed
23 Jun 2022Reviewer(s) Assigned
26 Jun 2022Review(s) Completed, Editorial Evaluation Pending