Effects of general anesthesia and ultrasonography-guided interscalene
block on pain and oxidative stress in shoulder arthroscopy: a randomized
Background/aim: The aim of this study was to evaluate the effects of
general anesthesia and ultrasonography-guided interscalene block on pain
and oxidative stress evaluated by thiol–disulphide balance and
C-reactive protein levels in patients undergoing shoulder arthroscopy.
Materials and methods: A total of 42 patients aged 18–75 years who were
scheduled to undergo shoulder arthroscopy were randomized into
interscalene block group (Group-IB, n = 20) and general anesthesia group
(Group-GA, n = 22). All patients received patient-controlled analgesia
during the postoperative period. Additional analgesics were administered
to patients with a visual analog scale score of > 4. Native
-thiol, total -thiol, disulphide and C-reactive protein levels were
measured. Patients’ visual analog scale scores, morphine and additional
analgesic consumption were recorded. A shift in thiol–disulphide
balance toward decreased thiol and increased disulphide levels was
regarded as an indicator of oxidative stress. Results: Pain level,
morphine and additional analgesic consumption were higher in Group-GA.
Native-thiol and total-thiol levels were higher in Group-IB
postoperatively and also disulphide levels were lower at postoperative
18 hours. C-reactive protein levels were similar in both the groups.
Conclusion: Interscalene block induced less oxidative stress during the
postoperative period, as evaluated by thiol–disulphide balance.