Evidence-based medicine has shown for many years that homozygous mutations of the HFE gene H63D are by no means negligible. Not only can it cause, usually after a second hit, rather mild classical hemochromatosis, but it can also cause numerous other disorders of iron metabolism, such as hypotransferrinemia, changes in binding capacity, and others. In addition, it may lead - among other symptoms - to damages of the heart and the substantia nigra via a causal relationship that remains to be investigated, most likely via a cascade dysfunction in iron metabolism. The clinical facts are compelling. Any physician who dismisses mutations of the HFE gene H63D as clinically irrelevant risks the health and life of his patient. We report two patients with an HFE H63D mutation who were treated almost too decades too late because of outdated expertise.

Skin cancer, especially malignant melanoma, can vary greatly in appearance and usually develops very quickly. Therefore, the ABCDE rule (also known as the ABCD rule in some countries) was propagated many years ago to help medical laymen to recognize for themselves when it is time to see a dermatologist. But how effective is this rule? Our previous work clearly demonstrates that another self-monitoring protocol has a higher sensitivity and better results than the outdated ABCDE rule: the C-Rapid-H-Plus Protocol. Based on this, a simple algorithm was developed which appeared to give quite promising results. Now we can present a completely new algorithm that has proven to be more reliable than dermatoscopy in predicting the need for excisional biopsy in a collective of 421 patients. The CRHP Advanced Risk Calculator, also based on the C-Rapid-H-Plus protocol, is of great value for both, in-person and telemedicine settings.

Skin cancer, especially malignant melanoma, can vary greatly in appearance and usually develops very quickly. Therefore, the ABCDE rule (also known as the ABCD rule in some countries) was propagated many years ago to help medical laymen to recognize for themselves when it is time to see a dermatologist. But how effective is this rule? Our previous work clearly demonstrates that another self-monitoring protocol has a higher sensitivity and better results than the outdated ABCDE rule: the C-Rapid-H-Plus Protocol which has also become an important tool in tele-dermatology.

During the development of a vaccine to protect against the Sars-CoV-2 virus, it became apparent that the targeted agent could lead to false positive results in the usual tests for HIV1/2 antibodies. The project was subsequently terminated and the topic disappeared from the attention of science and the media. Thanks to access to anonymized patient data through our international network and case reports within our own reporting system for unusual events, we have come to the hypothesis that this "Australian effect" can also occur with other Sars-CoV-2 vaccines, albeit to a much lesser extent. In individual cases, however, this can have dramatic consequences. For this reason, we are publishing a hypothesis, contrary to our usual conventions. In no way do we wish to minimize the willingness to get vaccinated, nor do we wish to reproach any pharmaceutical company. Nevertheless, it is important to present the facts as they appear to us for discussion and to avoid adverse consequences should such an effect actually materialize in individual cases.

As a result of recommendations from some influencers on vitamin D as a helpful supplement against Covid-19, the number of people taking vitamin D as a regular dietary supplement has increased, as has the amount of the dose taken individually. As a globally active health network, the Lazar Medical Consortium Group (LCG) has access to privacy-protected patient data in more than 25 countries. We searched the records of 14.742 patients worldwide for vitamin D intake on record, onset as well as duration of intake, and symptoms coded according to ICD-10 that were consistent with vitamin D-related hypervitaminosis. The evaluation revealed evidence of a worldwide overuse of vitamin D so massive that medical providers working with the Lazar Medical Consortium Group have all received a Red Label Notice to educate patients at every patient contact against the danger of taking too much vitamin D (>1000. I.U. per day).

Chris Wymant and an entire armada of scientists published a small paper titled "A highly virulent variant of HIV-1 circulating in the Netherlands." The general media have picked up on this and are giving the impression that HIV is now a more dangerous infection. This is not the fault of the Wymant and colleagues, but it is highly problematic. This more than 30 years old knowledge, which is now published with big headlines outside the medical press as lurid news, is likely to provoke misunderstandings in the general population. A renewed ostracism and stigmatization of the usual risk groups is now a real prospect. The findings presented in the aforementioned paper should have been addressed exclusively to health professionals and should have better never ended up in the hands of commercial media.

Chronic obstipation complaints are among the most common health disorders worldwide, with a prevalence of up to 20%, increasing with age and affecting women significantly more often than men. Neurological disorders are the cause in about 12% of these cases, often aggravated by the inevitably potent medication for these conditions. The management of these cases is the subject of this study report. Its outcome dispels prejudice and warns of malpractice in an area where the symptom burden of patients is often very high, multifaceted, and disabling. Finding the most reliable and safe method to ameliorate chronic constipation, which is often painful and causing hemorrhoids, is therefore the key to an overall improvement in the quality of life of these patients.

For many patients with severe Covid-19 disease of the pre-Omicron era, recovery is far from over with the end of acute symptoms. The authors of this paper have reviewed the currently available studies and conclude that Long-Covid appears to be a serious, sometimes even life-threatening syndrome. However, it seems to have good prospects for full recovery with multidisciplinary and evidence-based post-treatment care, which is, however, still lacking in Europe and North America. The Omicron variant appears to be a game changer in this regard as well. So far it seems that Long Covid is no common consequence of Sars-2-Omicron Disease.

The emergence of the Sars-CoV-2 Omicron variant(s) was a tipping point which led from the 2020/2021 Covid-19 pandemic to a surprisingly early endemic situation. Contrary to what is discussed by some virologists, a replacement of Sars-CoV-2 Omicron by another variant that produces more clinically problematic courses is only a theoretical possibility. In real life this will not happen. Instead Omicron seems to be even less lethal than the endemic hCoVs we have been knowing for decades. Therefore, now is the time to develop entirely new vaccines, not only against the Sars-CoV-2 virus but also to protect vulnerable populations against the human coronaviruses OC43, HKU1, 229E, and NL63. These coronaviruses are, as of early 2022, a greater public health threat than the Sars-CoV-2 virus with its Omicron variants.

The emergence of the Omicron variant (and its derivatives) was a tipping point from the 2020/2021 Covid-19 pandemic to a surprisingly early endemic situation. Contrary to what is sometimes discussed, a replacement of Sars-CoV-2 Omicron by another variant that produces more clinically problematic courses is only a theoretical possibility; in practice, it will not happen. Therefore, now is the time to tailor new vaccines not only against the Sars-CoV-2 virus, but also to protect entire populations against OC43, HKU1, 229E, and NL63, which have been known for a long time. These coronaviruses are, as of February 2022, a greater public health threat than the Sars-CoV-2 virus in its Omicron variant.

There is still debate in the virological community about whether the Omicron variant of the Sars-CoV-2 virus means its end as a pandemic virus and whether the endemic phase is already beginning-or not. We venture the hypothesis that Covid-19 is already a virus which is very similar to the four endemic seasonal coronaviruses and poses a relatively low risk to fully (3x) vaccinated individuals and to individuals who have recovered from infections with other Sars-CoV-2 variants in 2019 to 2022. For this reason, it would now make sense to develop vaccines and drugs that are effective against all known endemic human coronaviruses (hCoV), which are often lamentably misleadingly referred to as "cold viruses," rather than limiting new vaccines to the Omicron variant or to any other variant. Such a bold step would be a milestone in protecting the vulnerable population that has been at the mercy of classic hCoV viruses for centuries without effective protection.

The number of diagnoses of mental illness has been increasing for years, especially in the wealthy industrialized nations. What continues to be overlooked is the massive influence of the lobby of the psychotherapeutic "industry", which has long and steadily earned good money from hastily misdiagnosed patients. However, this can be a matter of moderate to severe malpractice.