Aim: to design and implement a medication reconciliation protocol led by clinical pharmacists that allowed to identify, characterize and, eventually, prevent antiparkinsonian medication errors to promote therapeutic quality and safety in daily practice. Methods: This was an interventional, single-center, one-year, prospective study analyzing the impact of developing an antiparkinsonian medication reconciliation program. All the patients who were hospitalized and had, at least, one active prescription containing an antiparkinsonian drug at hospital admission were included. The medication reconciliation was performed by following a three-phased check: inpatient electronic prescription validation after assessing the outpatient medication schedule, review of the latest clinical report emitted by the Neurology Department, and pharmacist-driven interview of the patient and/or caregiver to confirm the information regarding medication gathered. Results: 171 admission episodes from 132 patients were registered between February 1, 2021, and January 31, 2022. Of 224 prescription lines involving antiparkinsonian drugs, 179 contained, at least, one medication error (59.8%). Commission errors (91.62%) were more frequent than omitted drugs (8.38%). The most common medication errors were related to timing (41.90%), frequency (21.23%), and dosing (19.55%). The implementation of the medication reconciliation program prevented the erroneous administration of 2716 antiparkinsonian doses, 60% of the total number of doses prescribed during this period. Interestingly, a significant relationship between the number of medication errors and having levodopa prescribed was evidenced (p<0.05). A contraindicated drug was prescribed in almost one-third of the episodes (29.82%). Conclusion: Clinical pharmacists’ implementation of an antiparkinsonian medication reconciliation program sharply reduced medication errors, and contraindicated drugs prescription.

Background: Midurethral sling surgery is the current gold standard worldwide for stress urinary incontinence (SUI) surgery. However, concerns surround mesh-related adverse events associated with the midurethral sling. The decision to use the midurethral sling for surgical treatment has become a challenging one for clinicians, surgeons and patients. Objectives: We sought to determine the factors for 5-year complications after midurethral sling surgery, to improve the clinical decision-making process. Study Design: Records were reviewed from a total of 1,961 female patients who underwent their first midurethral sling surgery for SUI between 2003 and 2018 at a single teaching hospital in Taiwan. A multivariable Cox proportional hazard model calculated the hazard ratios of risk factors for surgical complications, after adjusting for confounders. Results: Surgical complications (i.e., secondary surgery and urinary retention) occurred in 93 (4.7%) patients within 5 years following the index operations. These patients were more likely to be older, to have a history of menopausal syndrome within 1 year prior to the index operation,hormone replacement therapy (HRT), slower average flow rate, and longer voiding time compared with patients without surgical complications. In the multivariate analysis, menopausal syndrome or HRT (adjusted hazard ratio, 1.794; 95% confidence interval, 1.055–3.050, p=0.0390) was significantly associated with surgical complications at 5 years, after adjusting for age, gender, diabetes, average flow rate, and sling type. Conclusion: Our findings suggest that a history of menopausal syndrome within 1 year prior to surgery or a medication history of HRT may be risk factors associated with surgical complications

Objective To investigate the relationship between serum fructose and uric acid levels in patients with polycystic ovary syndrome (PCOS). Design A case-control study. Setting University-affiliated in vitro fertilization clinic. Population 292 patients with PCOS and 482 controls. Main Outcome Measures Serum fructose, uric acid and metabolic measurements. Results Compared with controls, serum fructose and uric acid levels were significantly increased in women with PCOS and patients with PCOS accompanied by metabolic disorders exhibited higher serum fructose and uric acid levels (P < 0.001). Restricted cubic splines indicated that serum uric acid levels linearly and positively correlated with serum fructose levels in women with PCOS (Poverall < 0.001, Pnon-linear = 0.30), whereas no correlation was found in controls (Poverall = 0.712, Pnon-linear = 0.43). Additionally, even after adjusting for confounding factors, serum fructose levels were an independent risk factor for hyperuricemia in patients with PCOS (P = 0.001; odds ratio, 1.380; 95% confidence interval, 1.207–1.577). Conclusions There was a significantly positive association of elevated uric acid levels with serum fructose levels in PCOS and was closely correlated with PCOS-related metabolic disorders, highlighting the importance of further research into the biological mechanisms of fructose and uric acid in the development of PCOS. Funding National Natural Science Foundation of China (No. 82071607 and 32100691); LiaoNing Revitalization Talents Program (No. XLYC1907071); Fok Ying Tung Education Foundation (No. 151039); Key Research and Development Program of Liaoning Province (No. 2018225062); Outstanding Scientific Fund of Shengjing Hospital (No. 202003). Keywords Fructose; Uric acid; PCOS; Metabolic disorder

In order to balance the relationship between the protection of personal information and the use of personal information, the Personal Information Protection Law has set anonymization standards. Although, technically, absolute anonymity is not achievable, but the legal goals are not the same as the technical goals. In order to maximize social welfare, it is necessary to reduce the quality of anonymization to a certain extent to ensure the universality and speed of the personal information governance program. Therefore, it becomes feasible to realize the anonymization of personal information in law. In order to facilitate the anonymization of judgments, different jurisdictions have established different rational people standards under the guidance of value. The EU standard overemphasizes the protection of the rights of information subjects, which is not conducive to the use of personal information, and it is difficult to maximize social benefits. The Anglo-American standard takes into account both “security” and “efficiency”, while protecting the information subject, while leaving enough space for personal information processors. Among them, the United States compromises the adoption of abstract standards and specific standards, which overcomes the impracticality of adopting abstract standards alone. The shortcomings of non-predictability and other specific standards.

Background and Purpose: Blood-brain barrier (BBB) breakdown is one of the most crucial pathological changes of cerebral ischemia-reperfusion (I/R) injury. Trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effect against cerebral I/R injury as demonstrated in our previous study. This study was designed to investigate the effect of TLB on disruption of BBB after cerebral I/R injury. Experimental Approach: Rats with focal cerebral ischemia caused by transient middle cerebral artery occlusion (MCAO) and brain microvascular endothelial cells along with human astrocytes to mimic blood brain barrier (BBB) injury caused by oxygen and glucose deprivation (OGD) followed by reoxygenation (OGD/R). Key results: The results showed that TLB effectively maintained the integrity of BBB and inhibited neuronal loss following cerebral I/R challenge. Furthermore, TLB dramatically increased tight junction proteins including ZO-1, occludin and claudin 5, as well as decreased the levels of apolipoprotein E (APOE) 4, cyclophilin A (CypA), and phosphorylated nuclear factor kappa B (NF-κB), thereby reduced proinflammatory cytokines. In addition, TLB also decreased Bax/Bcl-2 ratio and cleaved-caspase 3 level along with reduced the number of apoptotic neurons. Intriguingly, molecular docking and transcriptomics predicted MMP9 was a prominent gene evoked by TLB treatment. Furthermore, the protective effect of TLB on OGD/R-induced the loss of BBB integrity in human brain microvascular endothelial cell and astrocyte co-cultures in vitro was markedly reinforced by knockdown of MMP9. Conclusions and implications: Our findings reveal a novel property of TLB: saving BBB disruption following cerebral I/R via targeting MMP9 and inhibiting APOE4/CypA/NF-κB axis.

Background and Purpose: Cytokine storm invoked during acute and chronic lung injury promotes alveolar damage and remodeling. The current study shows that degraded elastin-targeted nanoparticles releasing doxycycline (Doxy NPs) are potent in mitigating cytokines storm, migration of immune cells in the lungs, and inhibiting inflammasome pathways in the LPS mouse model. Experimental Approach: Cytokine storm and lung injury were induced using LPS and elastase in C57BL/6 mice (rodent model for emphysema). The mice were then treated with I.V. Doxy NPs, blank NPs, or Doxy a day before LPS administration. Cytokine levels, immune cell population, and MMP activity were analyzed in BALF 4 hours after LPS administration. Additionally, gene expression of IL-6, IL-1beta, MCP-1, NLRP3, Caspase 1, and MMPs were investigated in alveolar cells on day three after LPS administration. Key Results: Doxycycline NPs but not Doxycycline significantly decreased IL-6, TNF-α, and IL-23 and were significantly more effective in decreasing the percentage of immune cells in the BALF. This is the first in-vivo study to demonstrate that Doxycycline can effectively inhibit lung inflammasome pathways. Conclusion and Implications: IV administration of elastin antibody conjugated Doxycycline-loaded albumin Nps can effectively modulate the local immune environment in the lungs, which is not achieved by IV Doxycycline even at a 100-fold higher dose. This novel method of drug delivery can effectively lead to the repurposing of traditional Doxycycline as a potential adjunct treatment for managing the cytokine storm in the lungs in COPD and viral infections.

Resource fluctuation is a major driver of animal movement, influencing strategic choices such as residency vs nomadism, or social dynamics. The Arctic tundra is characterized by strong seasonality: resources are abundant during the short summers but scarce in winters. Therefore, expansion of boreal-forest species onto the tundra raises questions on how they cope with winter-resource scarcity. We examined a recent incursion by red foxes (Vulpes vulpes) onto the coastal tundra of western Hudson Bay, an area historically occupied by Arctic foxes (Vulpes lagopus) that lacks access to anthropogenic foods, and compared seasonal shifts in space use of the two species. We used 4 years of telemetry data following 8 red foxes and 11 Arctic foxes to test the hypothesis that the movement strategies of both species are primarily driven by temporal variability of resources. We also predicted that the harsh tundra conditions in winter affect red foxes more than Arctic foxes, which are adapted to this environment. Dispersal was the most frequent winter movement strategy in both fox species, despite its association with high mortality (winter mortality was 9.4 times higher in dispersers than residents). Red foxes consistently dispersed towards the boreal forest, whereas Arctic foxes primarily used sea ice to disperse. Home range size of red and Arctic foxes did not differ in summer, but resident red foxes substantially increased their home range size in winter, whereas home range size of resident Arctic foxes did not change seasonally. As climate changes, abiotic constraints on some species may relax, but associated declines in prey communities may lead to local extirpation of many predators, notably by favoring dispersal during resource scarcity.

Aim: Species’ environmental requirements and large-scale spatial and evolutionary processes are known to determine the structure and composition of local communities. However, ecological interactions and historical processes also have major effects on community assembly at landscape and local scales. In this work we evaluate whether two xerophytic shrub communities follow fixed ecological assembly dynamics throughout large geographical extents, or their composition is rather driven by species individualistic responses to environmental and macroecological constraints. Location: SW Iberian Peninsula (Portugal and Spain) Taxa: Stauracanthus genistoides agg. and Ulex australis agg (Fabaceae). Methods:Inland dune xerophytic shrub communities were sampled in 95 plots distributed within their potential area of occurrence. Then, we described the main gradients of vegetation composition and assess the relevance of biotic interactions. We also characterized the habitat suitability of the dominant species, S. genistoides and U. australis, to map the potential distribution of the xerophytic shrub communities. Finally, to identify the relative importance of each factor driving changes in community composition, we examined the relationships between the vegetation gradients and a broad set of explanatory variables. Results: Our results show that xerophytic shrubs follow uniform successional patterns throughout the whole geographical area, but also that these communities respond differently to the main environmental gradients in each region. Soil organic matter is the main determinant of community variations in the northern regions, Setúbal Peninsula and Comporta, while in the South/South-Western region most of the variation between both types of communities is explained by temperature seasonality. Main conclusions: The relative importance of the main factors causing community-level responses varies according to regional processes and the suitability of the environmental conditions for the dominant species in these communities. These responses are also determined by intrinsic community mechanisms that result in a high degree of similarity in the gradient-driven community stages in different regions.

Whole-genome sequencing for generating SNP data is increasingly used in population genetic studies. However, obtaining genomes for massive numbers of samples is still not within the budgets of many researchers. It is thus imperative to select an appropriate reference genome and sequencing coverage to ensure the accuracy of the results for a specific research question, while balancing cost and feasibility. To evaluate the effect of the choice of the reference genome and sequencing coverage on downstream analyses, we used five confamilial reference genomes of variable relatedness and three levels of sequencing coverage (3.5x, 7.5x and 12x) in a population genomic study on two caddisfly species: Himalopsyche digitata and H. tibetana. Using these 30 datasets (five reference genomes × three coverages × two target species), we estimated population genetic indices (inbreeding coefficient, nucleotide diversity, pairwise and genome-wide FST) based on variants and population structure (PCA and admixture) based on genotype likelihood estimates. The results showed that both distantly related reference genomes and lower sequencing coverage lead to degradation of resolution. In addition, choosing a more closely related reference genome may significantly remedy the defects caused by low coverage. Therefore, we conclude that population genetic studies would benefit from closely related reference genomes, especially as the costs of obtaining a high-quality reference genome continue to decrease. However, to determine a cost-efficient strategy for a specific population genomic study, a trade-off between reference genome relatedness and sequencing depth can be considered.

Fundamental oil of Mentha piperita are perplexing blends detached from sweet-smelling plants which may have antimicrobial, cooling receptor trigger, pesticidal, anticancer, hack, asthma, and use in painkiller, exercises of enthusiasm for the sustenance and corrective enterprises just as in the human well-being field in pharmaceutical. According to the German Commission E monographs, peppermint oil is greatly employed as an antispasmodic in the stomach and intestine in bile channel and for the treatment of peevish entrails disorder, inflammation of the respiratory tract, and aggravation of the oral mucosa. Remotely, M. piperita has been employed for myalgia and neuralgia. As indicated by German Commission E, M. piperita may likewise go about as a carminative, disinfectant, and pectolytic, having soothing activity. Enteric-covered peppermint oil containers (Colpermin) are mostly employed as an orally controlled antispasmodic premedication in the study of large intestine.

Nanoscale materials that are found in many kinds at nano scale stage. Nanoparticles are vast class of material that contain small discrete mass of matter which have one particular range from 1-100nm. Nanoparticles are zero dimension, two dimensions and three dimensions etc. There are broad class of Nanoparticles which is used in disease diagnosis and treatment. Nanoparticles collaborated with the drug and increase the effectiveness of the target object. Surface of nanoparticles is modified with many agents and used in different disease. One of best purpose of nanoparticles is in drug delivery. Nanoparticles are not effective in human diseases but also helpful in plant disease. Different nanodevices like nanowires and cantilevers are very effective for gastrointestinal diseases. Specialists at Osaka University have joined nanopore sensors with man-made brainpower methods and showed that they can recognize single infection particles. This technique may give fast, purpose of utilization, ID of infections. A strategy for recognizing malignancy cells in the circulation system is being created utilizing nanoparticles called NanoFlares. The NanoFlares are structured tie to hereditary focuses in disease cells, and create light when that specific hereditary objective is found. Nanoparticles uses in different methods like MRI increased its efficiency for imaging. Many of imaging techniques like ultrasound imaging (USI), magnetic resonance imaging (MRI) and optical imaging (OI) ultrasound imaging (USI) for study of inside and outside study of human beings and others. There are different types of nanoparticles used in these techniques which help in vivo and vitro study. For treatment purpose, DNA vaccine coated SiO2 (LDH) nanoparticles induced antibody is used mostly. For this, nano spray recently discovered that picks up the insects. So, role of nanoparticles is effective.

Four allotropes of phosphorus namely, red, violet, white, and black phosphorus (phosphorene) named rendering to their entrance. Phosphorene few or maybe monolayer of black Phosphorus having bags of submissions in optoelectronics and electronic devices. Research is going to its belongings and device presentations has since understood exponential growth. So, we will investigating the tropical development in phosphorene study, moving up on the topics of Electronics and optoelectronics things and uses. We also confer upcoming development investigation and some tasks. We will also highpoint the phosphorene optoelectronic and electronic belongings resulting from phosphorene wrinkly construction which is different from graphene. The new the new properties of phosphorene will be moved design and protest of new devices but extra development joints on resolves to mechanical fences as surface degrading belongings and non-scalable manufacture methods. We temporary define the modern expansions of additional sophisticated project thoughts and application systems which report some of the tasks in black Phosphorus enquiry. This is predictable that attractive material remain to offer great breaks of research and evolution for predictable future. Different EDGE functionalization groups like at H, OH, COOH, and NH2 are studied for chain extent. ______________________________________________________________________________________________ _ Introduction The Brandt, in 1969 was discovered first time phosphorus the 11 th abundant element of earth crust (Lehman,

Spices are the structure squares of flavor in food. Their essential capacities are to give fragrance, surface what's more, shading to food. Moreover they likewise go about as additive, and give dietary, and medical advantages. Cumin (Cuminum cyminum) privately known as 'zeera' is a blooming plant in the family Apiaceae. It is generally utilized as a topping and seasoning in numerous eastern dishes. Cumin is known for its cell reinforcement properties. Despite the fact that the seeds of cumin (Cuminum cyminum L.) are generally utilized as a flavor for their unmistakable smell, they are likewise regularly utilized in customary medication to treat an assortment of ailments. The writing presents plentiful proof for the biomedical exercises of cumin, which have for the most part been attributed to its bioactive constituents, for example, terpenes, phenols, and flavonoids. Various pre-clinical and clinical preliminaries have explored its adequacy utilizing the seed oil, basic oil, and its fundamental constituent thymoquinone (TQ). Different investigations made in the most recent decades approve its wellbeing useful impacts especially in diabetes, dyslipidemia, hypertension, respiratory issues, fiery illnesses, and disease. These examinations uphold its utilization either autonomously or as an assistant alongside ordinary medications in respiratory issues, unfavorably susceptible rhinitis, dyspepsia, metabolic disorder, diabetes mellitus, provocative infections, and various kinds of human disease.

Nanotechnology deals with the study and manipulation of materials on an atomic or a molecular scale almost less than 100 nm. Nanotechnology encompasses the synthesis and applications of biological, chemical and physical systems which ranges from individual atom to molecular or submicron level. It is the more interesting field for the scientists due to various applications in different fields of science e.g., biomedical engineering, material science, medicine and electronics at nanoscale level. The particles ranges from 1 to 100 nm by a surrounded interfacial layer are basically called nanoparticles. Ag nanoparticles are the most fascinating and vital nanoparticles amongst the other metallic nanoparticles like gold, tin, palladium etc. In this review literature, the synthesis and properties of Ag nanoparticles have been discussed. Herein, main area of study interest is to find biomolecules by using conventional as well as colorimetric detection methods with silver nanoparticles. Synthesis and characterization of Ag nanoparticles is an immense attention in nanotechnology due to its wide range applications in industries. Ag nanoparticles are synthesized by different methods (physical, chemical, biological and photochemical methods), amongst these methods green synthesis method is most favorable method, because it is cost effective and eco friendly method. Ag nanoparticles have various significant properties such as antibacterial, antifungal, antiviral, anti-cancer, and anti-angiogenic etc. Nanoparticles possess many applications in different fields of life e.g., medicine, biomedical devices, multicolor optical coding, manipulation of biomolecule (proteins, DNA, cysteine), environmental remediation and cosmetics. The aim of prospective applications is to investigate the colorimetric and optical detection of biomolecule by Ag nanoparticles, e.g., dopamine, proteins, DNA etc. because of its highly sensitivity and selectivity. The colorimetric detection of various biomolecules by Ag nanoparticles has inherent chirality. Ag nanoparticles provides high surface to volume ratio and function for detection of proteins, nucleic acid, ions and molecules. Ag nanoparticles as colorimetric probes and chiral selector are helpful in determining citalopramenantiomers. However, we can easily read out the assay described in this work with naked eye and by use of ultra violet spectrometer. [Shahzad Sharif Mughal, Faheem Abbas, Muhammad Usman Tahir, Ali raza ayub, Hafiza Maria javed, Muhammad mamtaz, Hafiza iram. Role of Silver Nanoparticles in Colorimetric Detection of Biomolecules. Biomedicine and Nursing 2019;5(4): 31-47].

The liver is one of the vital organs in the body, and the gold standard of treatment for liver function impairment is liver transplantation, which poses many challenges. The specific 3D structure of liver, which significantly impacts the growth and function of its cells, has made biofabrication with the 3D printing of scaffolds suitable for this approach. In this study, to investigate the effect of scaffold geometry on the performance of HepG2 cells, Poly-Lactic acid (PLA) polymer was used as the input of the Fused Deposition Modeling (FDM) 3D-printing machine. Samples with simple square and bioinspired hexagonal cross-section designs were printed. 1% and 2% of gelatin-coating were applied to the 3D printed PLA to improve the wettability and surface properties of the scaffold. SEM pictures were used to analyze the structural properties of PLA-Gel hybrid scaffolds, EDS to investigate the presence of gelatin, water contact angle measurement for wettability, and weight loss for degradation. In vitro tests were performed by culturing HepG2 cells on the scaffold to evaluate the cell adhesion, viability, cytotoxicity, and specific liver functions. Then, high-precision scaffolds were printed and the presence of gelatin was detected. Also, the effect of geometry on cell function was confirmed in viability, adhesion, and functional tests. The albumin and urea production of the Hexagonal PLA scaffold was about 1.22 ­±0.02 fold higher than the square design in 3 days. This study will hopefully advance our understanding of liver tissue engineering toward a promising perspective for liver regeneration.

Herein we report the use of Pseudomonas putida F1 biofilms grown on carbonized cellulosic fibers to achieve biodegradation of airborne VOCs in the absence of any bulk aqueous phase media. It is believed that direct exposure of gaseous VOC substrates to biomass may eliminate aqueous phase mass transfer resistance and facilitate VOC capture and degradation. When tested with toluene vapor as a model VOC, the supported biofilm could grow optimally at 300 ppm toluene and 80% relative humidity, with a specific growth rate of 0.425 day -1. During long-term VOC biodegradation tests in a tubular packed bed reactor, biofilms achieved a toluene degradation rate of 2.5 mg g DCW -1 h -1 during the initial exponential growth phase. Interestingly, the P. putida F1 film kept biodegrading activity even at the subsequent stationary non-growth phase. The supported biofilms with a biomass loading of 20% (wt) could degrade toluene at a rate of 1.9 mg g DCW -1 h -1 during the stationary phase, releasing CO 2 at a rate of 6.4 mg g DCW -1 h -1 at the same time (indicating 100% conversion of substrate carbon to CO 2). All the specific degradation rates are much higher than what can be gleaned from previously reported work. It also demonstrates the feasibility of biofilm growth and direct gas phase degradation of VOCs without requiring any bulk aqueous phase.

Coronavirus disease 2019 (COVID-19) is the most prevalent disease in society today, and vaccination is a powerful weapon against COVID-19. However, there have been many recent reports of vaccine-induced skin side effects. Autoimmune bullous reactions caused by the COVID-19 vaccine are rare. We identified a case of refractory PV associated with COVID-19 vaccination that improved after 2 RTX injections.

Most studies exploring land use impacts have focused on taxonomic metrics, but interest in the functional approach has increased because it helps to understand the relationships between community structure and functioning of aquatic ecosystems. We evaluated how functional and taxonomic approaches contribute to assessing the effects of land use on macroinvertebrate assemblages of lowland streams. We also studied the relationships between both approaches. We sampled benthic macroinvertebrates in 17 sites with different land uses (agricultural, peri-urban, and extensive livestock). We computed the taxonomic metrics and biotic indexes as well as functional richness (FRic), divergence (FDiv), dispersion (FDis), and Rao diversity indexes for each site. We performed general linear mixed models to compare land-uses and also performed correlation analysis between taxonomic and functional indexes. Taxonomic richness was significantly higher in extensive livestock than in the other two land uses, while Shannon diversity was significantly different between land uses (extensive livestock>peri-urban>agriculture). FRic and FDiv were significantly lower in peri-urban land use than in agricultural and extensive livestock sites. Only taxonomic richness showed a significant and positive relationship with FRic, FDis, and Rao, but they fit better to a logarithmic function. Therefore, an increase in taxonomic richness and Shannon diversity did not necessarily imply an increase in the functional aspects of the macroinvertebrate assemblage. Using only one of these approaches could lead to partial evaluations and loss of information. Combining them could improve bioindication and predictive potential and help assess the effects of multiple stressors on freshwater ecosystems to improve biomonitoring.

The increasing use of milk proteins in medicine requires the development of effective processes for sterilization of milk formulations. We found that epigallocatechin-3-gallate (EGCG) was able to reduce bacterial flora in total casein, depending on the concentration of EGCG. Furthermore, the combination of EGCG and gamma radiation reduced the dose D10 to 0.88 kGy and 0.63 kGy with 250 and 500 µM EGCG, respectively, instead 2.01 kGy without EGCG. We also examined the effect of gamma radiation on alpha- and beta-casein in the absence and presence of epigallocatechin-3-gallate (EGCG). Milk proteins in solution were exposed to different doses of gamma radiation with and without EGCG. Unirradiated and irradiated samples were analyzed by SDS-PAGE and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-MS). Our results suggest that EGCG (10 µM) protects α- and β-casein from degradation and subsequent polymerization, possibly by scavenging oxygen and protein free radicals generated during irradiation. Although we used a ratio of polyphenols to protein that was higher for alpha-casein (1/5) than beta-casein (1/10), beta-casein was better protected with EGCG. According to previous studies, this result could be explained by differences in protein primary structure and its interaction with EGCG. The interaction of EGCG with casein is hydrophobic rather than hydrophilic, so the interaction with β-casein is stronger than with α-casein. In conclusion, we found that low EGCG concentrations enhances the sterilization of total casein by gamma radiation and it provided an excellent radioprotection of α- and β-casein, especially β-casein, against degradation and aggregation.

We report two cases of Schloffer tumor that required resection after radical colon cancer surgery because of suspected lymph node recurrence on contrast-enhanced (CE) CT and 18F-FDG-PET/CT.Case1 is 69-year-old man with sigmoid colon cancer pStage IIA and case 2 is a 67-year-old male with descending colon cancer pStage IIIB.

Persistent left superior vena cava (SVC) without the right SVC is very rare and occurs in 0.07%–0.13% of patients with congenital heart defects. An enlarged coronary sinus detected during cardiac examination in the prenatal period is the first finding that raises suspicion for this anomaly. In this report, a patient was presented who was referred with the prediagnosis of cor triatriatum sinister in the antenatal period and diagnosed with isolated persistent left SVC.

Hemorrhagic cholecystitis is a rare complication of acute cholecystitis. Hemorrhage in the gallbladder can occur for a variety of reasons (gallstone cholecystitis, secondary to trauma, percutaneous procedures, neoplasms, bile parasites, or disorders of hemostasis).CT scan can help the diagnosis. We report a case of hemorrhagic cholecystitis complicated by gallbladder perforation

From decomposition method for operators, we consider Newton-like iterative processes for approximating solutions of nonlinear operators in Banach spaces. These iterative processes maintain the quadratic convergence of Newton's method. Since the operator decomposition method has its highest degree of application in non-differentiable situations, we construct Newton-type methods using symmetric divided differences, which allow us to improve the accessibility of the methods. Experimentally, by studying the basins of attraction of these methods, observe an improvement in the accessibility of derivative-free iterative processes that are normally used in these non-differentiable situations, such as the classic Steffensen's method. In addition, we study both the local and semi-local convergence of the Newton-type methods considered.

We propose a modification of a method based on Fourier analysis to obtain the Floquet characteristic exponents for periodic homogeneous linear systems, which shows a high precision. This modification uses a variational principle to find the correct Floquet exponents among the solutions of an algebraic equation. Once we have these Floquet exponents, we determine explicit approximated solutions. We test our results on systems for which exact solutions are known to verify the accuracy of our method including one dimensional periodic potentials of interest in quantum physics. Using the equivalent linear system, we also study approximate solutions for homogeneous linear equations with periodic coefficients.