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Effects of non-steroidal anti-inflammatory drugs and other eicosanoid pathway modifiers on antiviral and allergic responses. EAACI task force on eicosanoids consensus report in times of COVID-19
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  • Milena Sokolowska,
  • G Enrico Rovati,
  • Zuzana Diamant,
  • Eva Untersmayr,
  • Jürgen Schwarze,
  • Lukasik Z.,
  • Florentina Sava,
  • Alba Angelina,
  • Oscar Palomares,
  • Cezmi Akdis,
  • Liam O'Mahony,
  • Milos Jesenak,
  • Oliver Pfaar,
  • María José Torres,
  • Marek Sanak,
  • Sven-Erik Dahlén,
  • Grzegorz Woszczek
Milena Sokolowska
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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G Enrico Rovati
University of Milan Graduate School in Social and Political Sciences
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Zuzana Diamant
Lunds Universitet Lungmedicin och Allergologi
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Eva Untersmayr
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Jürgen Schwarze
The University of Edinburgh Edinburgh Medical School
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Lukasik Z.
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Florentina Sava
University College London Great Ormond Street Institute of Child Health Library
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Alba Angelina
Complutense University of Madrid Bibliotecas
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Oscar Palomares
Complutense University of Madrid Bibliotecas
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Cezmi Akdis
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Liam O'Mahony
University College Cork
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Milos Jesenak
Department of Pulmonology and Phthisiology Department of Allergology and Clinical Immunology Department of Pediatrics Jessenius Faculty of Medicine in Martin Comenius University in Bratislava University Teaching Hospital in Martin Slovakia
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Oliver Pfaar
Philipps Universitat Marburg Kunstgeschichtliches Institut
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María José Torres
Universidad de Malaga
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Marek Sanak
Uniwersytet Jagiellonski w Krakowie Wydzial Lekarski
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Sven-Erik Dahlén
Karolinska Institutet Institutet for miljomedicin
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Grzegorz Woszczek
MRC and Asthma UK Centre in Allergic Mechanisms of Asthma
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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) and other eicosanoid pathway modifiers are among the most ubiquitously used medications in the general population. Their broad anti-inflammatory, antipyretic and analgesic effects are applied against symptoms of respiratory infections, including SARS-CoV-2, as well as in other acute and chronic inflammatory diseases that often coexist with allergy and asthma. However, the current pandemic of COVID-19 also revealed the gaps in our understanding of their mechanism of action, selectivity and interactions not only during viral infections and inflammation, but also in asthma exacerbations, uncontrolled allergic inflammation, and NSAIDs-exacerbated respiratory disease (NERD). In this context, the consensus report summarises currently available knowledge, novel discoveries and controversies regarding the use of NSAIDs in COVID-19, and the role of NSAIDs in asthma and viral asthma exacerbations. We also describe here novel mechanisms of action of leukotriene receptor antagonists (LTRAs), outline how to predict responses to LTRA therapy and discuss a potential role of LTRA therapy in COVID-19 treatment. Moreover, we discuss interactions of novel T2 biologicals and other eicosanoid pathway modifiers on the horizon, such as prostaglandin D2 antagonists and cannabinoids, with eicosanoid pathways, in context of viral infections and exacerbations of asthma and allergic diseases. Finally, we identify and summarise the major knowledge gaps and unmet needs in current eicosanoid research.

Peer review status:UNDER REVIEW

24 Nov 2021Submitted to Allergy
24 Nov 2021Assigned to Editor
24 Nov 2021Submission Checks Completed
26 Nov 2021Reviewer(s) Assigned