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Effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress in shoulder arthroscopy: a randomized trial
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  • MURAT ÖKSÜZ,
  • Suheyla Abitagaoglu,
  • Ahmet Kaciroglu,
  • Ceren Koksal,
  • Burak Yagmur Ozturk,
  • Özcan Erel,
  • Almila Senat Aydin,
  • Dilek Erdogan Ari
MURAT ÖKSÜZ
Sancaktepe Şehit Prof Dr Ilhan Varank Training and Research Hospital
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Suheyla Abitagaoglu
Fatih Sultan Mehmet Training and Research Hospital
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Ahmet Kaciroglu
Bursa City Hospital
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Ceren Koksal
Fatih Sultan Mehmet Training and Research Hospital
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Burak Yagmur Ozturk
Fatih Sultan Mehmet Training and Research Hospital
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Özcan Erel
Ankara Yildirim Beyazit Universitesi Tip Fakultesi
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Almila Senat Aydin
Ankara Yildirim Beyazit Universitesi Tip Fakultesi
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Dilek Erdogan Ari
Fatih Sultan Mehmet Training and Research Hospital
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Abstract

Background/aim: The aim of this study was to evaluate the effects of general anesthesia and ultrasonography-guided interscalene block on pain and oxidative stress evaluated by thiol–disulphide balance and C-reactive protein levels in patients undergoing shoulder arthroscopy. Materials and methods: A total of 42 patients aged 18–75 years who were scheduled to undergo shoulder arthroscopy were randomized into interscalene block group (Group-IB, n = 20) and general anesthesia group (Group-GA, n = 22). All patients received patient-controlled analgesia during the postoperative period. Additional analgesics were administered to patients with a visual analog scale score of > 4. Native -thiol, total -thiol, disulphide and C-reactive protein levels were measured. Patients’ visual analog scale scores, morphine and additional analgesic consumption were recorded. A shift in thiol–disulphide balance toward decreased thiol and increased disulphide levels was regarded as an indicator of oxidative stress. Results: Pain level, morphine and additional analgesic consumption were higher in Group-GA. Native-thiol and total-thiol levels were higher in Group-IB postoperatively and also disulphide levels were lower at postoperative 18 hours. C-reactive protein levels were similar in both the groups. Conclusion: Interscalene block induced less oxidative stress during the postoperative period, as evaluated by thiol–disulphide balance.

Peer review status:IN REVISION

05 Jun 2021Submitted to International Journal of Clinical Practice
05 Jun 2021Assigned to Editor
05 Jun 2021Submission Checks Completed
15 Jun 2021Reviewer(s) Assigned
22 Jun 2021Review(s) Completed, Editorial Evaluation Pending
24 Jun 2021Editorial Decision: Revise Major